Long Term Cognitive Impact of Pediatric Acute Renal Injury

University of Florida

Status: Completed

Conditions: Acute Kidney Injury

Treatments: Other: Pediatric Quality of Life (Peds QL) Survey

Study type: Observational

Funder types: Other

Identifiers

NCT02372734

IRB201401054

Details and patient eligibility

About

The research study will investigate the longitudinal cognitive outcomes in subjects admitted as children diagnosed with sepsis who may have had acute kidney injury. Each subject will be contacted 2-15 years after their incident admission in order to solicit responses to a functional and cognitive quality of life survey. Children admitted during the same time frame that did not have kidney injury will also be surveyed.

Full description

250 subjects with a prior admission for pediatric sepsis will be contacted 2-15 years following the incident admission in order to complete a survey to assess their overall quality of life. Children will be administered the Pediatric Quality of Life (PedsQL) survey with a parental section to allow for parental response. Adult subjects will take the adult version of the PedsQL.

Enrollment: 73 patients

Sex: All

Ages: 2 to 36 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects may be adults or children who were admitted to the hospital with a severe infection between January 1998 to December 2014.
• Consent from adult or parent/guardian of child to participate in study.
• Assent from subjects between 7 and 17 years of age.

Exclusion criteria

• Failure or inability to complete the survey
• Participant is unable to understand written or spoken English
• Subjects between 7 and 17 years of age unwilling to assent.

Trial design

73 participants in 2 patient groups

Sepsis with acute kidney injury (AKI)

Description:

Prior admission for sepsis with a diagnosis of AKI as a child. Intervention: The subjects will be administered the Peds QL survey.

Treatment:

Other: Pediatric Quality of Life (Peds QL) Survey

Sepsis without acute kidney injury (AKI)

Description:

Prior admission for sepsis without a diagnosis of AKI as a child. Intervention: The subjects will be administered the Peds QL survey.

Treatment:

Other: Pediatric Quality of Life (Peds QL) Survey