Long Term Diabetes Improvement After Cancer Gastrectomy and Colectomy

University of Sao Paulo

Status: Completed

Conditions: Prediabetes; Gastric Cancer; Diabetes Mellitus; Morbid Obesity; Colorectal Cancer

Treatments: Other: Interview, questionnaire, updated biochemical tests

Study type: Observational

Funder types: Other

Identifiers

NCT01518023

Lessdiabetes

Details and patient eligibility

About

There is evidence that gastrointestinal operations for non weight-losing purposes are beneficial for diabetes mellitus. Aiming to analyze such hypothesis, patients submitted to gastric bypass for morbid obesity, gastrectomy for gastric cancer and colectomy for colo-rectal cancer will be compared. The end point will be changes in fasting blood glucose and hemoglobin A1c concentration.

Full description

In a prospective protocol with retrospective information, patients (N=240) undergoing bariatric Roux-en-Y gastric bypass (n=80), cancer subtotal or total gastrectomy (n=80) and right colectomy or rectosigmoidectomy (n=80) with follow-up >3 years free of disease, with or without previously impaired fasting blood glucose, will be recruited. Patients will be submitted to a questionnaire involving diet, diagnosis of diabetes and glucose-lowering drugs, body weight and other clinical items. Preoperative information available in the hospital system will be completed and current findings will be updated, including body mass index and biochemical measurements. Using the outcomes of the bariatric population as benchmark, both concerning diabetics that were ameliorated and nondiabetics that progressed to new-onset diabetes,results in the other groups will be compared. The study should answer whether gastric and colorectal surgery for cancer 1) Are beneficial for established diabetes; 2) Attenuate the conversion of normal patients to diabetes, both within a follow-up period of 3- 12 years;

Enrollment: 240 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Follow-up period > 3 years,
• weight stable in the last year

Exclusion criteria

• Reoperation or take-down of original operation,
• consumptive diseases,
• protein-calorie malnutrition,
• organ failures,
• pancreatic surgery,
• cell or organ transplantation,
• type 1 diabetes,
• cognitive impairment or Alzheimer disease,
• refusal to participate in the protocol

Trial design

240 participants in 3 patient groups

Cancer gastrectomy

Description:

Patients previously submitted to partial/total gastrectomy for gastric cancer

Treatment:

Other: Interview, questionnaire, updated biochemical tests

Colorectal cancer operation

Description:

Patients previously submitted to right colectomy or rectosignoidectomy for cancer

Treatment:

Other: Interview, questionnaire, updated biochemical tests

Bariatric patients

Description:

Morbidly obese participants who underwent antiobesity Roux-en-Y gastric bypass

Treatment:

Other: Interview, questionnaire, updated biochemical tests