Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults

Mass General Brigham

Status: Completed

Conditions: Brain Injuries; Cognitive Decline; Nutrition, Healthy

Treatments: Dietary Supplement: Blueberry powder; Other: Controlled and matched powder

Study type: Interventional

Funder types: Other

Identifiers

NCT05764824

2022P002554

Details and patient eligibility

About

This study will test whether consuming blueberry powder 20g/d for 24 weeks can improve memory and other cognitive function and alter serum biomarkers of brain injury among older adults.

Full description

In a randomized, double-blind placebo, controlled design, the investigators will test the effects of 20 g/d of blueberry powder for 24 weeks on cognitive function and serum biomarkers of brain injury among older adults.

Enrollment: 67 patients

Sex: All

Ages: 65 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged 65-99 years
• Able to travel to Brigham and Women's Hospital for 4 clinic visits

Exclusion criteria

• Known allergies to blueberries
• Unable to abstain from blueberry consumption during the study period
• Inability to provide informed consent
• Planned major surgery during study period or recent major surgery up to 3 months before recruitment
• Organ transplant
• Plan to move out of greater Boston area during the study period
• Diagnosis of dementia, severe cognitive decline, end-stage renal disease, substance abuse, insulin-dependent diabetes mellitus, major cancer excluding non-melanoma skin cancer, and schizophrenia.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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67 participants in 2 patient groups, including a placebo group

Blueberry group

Active Comparator group

Description:

Blueberry arm

Treatment:

Dietary Supplement: Blueberry powder

Control group

Placebo Comparator group

Description:

Control arm

Treatment:

Other: Controlled and matched powder