Long-term Effects of Endobronchial Valve Implantation on Cardiac Function and Skeletal Muscle Function

China-Japan Friendship Hospital

Status

Enrolling

Conditions

Chronic Obstructive Pulmonary Disease

Treatments

Procedure: Lung volume reduction surgery with endobronchial valve implantation

Study type

Interventional

Funder types

Other

Identifiers

NCT05775588

2022-NHLHCRF-LX-01-0202-1

Details and patient eligibility

About

The goal of this type of study: clinical trial is to evaluate the effect of bronchial valve implantation on cardiac function and skeletal muscle function in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:evaluate the effect of bronchial valve implantation on cardiac function and skeletal muscle function.

Participants will undergo Lung volume reduction surgery with endobronchial valve implantation.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with Chronic Obstructive Pulmonary Disease
FEV1 ≤ 45% pred and FEV1/FVC<70%
TLC>100% pred and RV>175% pred
CAT score≥18
Emphysema damage>50%
Complete interlobar fissure >95% based on quantitative analysis of CT measurement
No smoking>6 months
Sign the informed consent form

Exclusion criteria

PaCO2>8.0 kPa, or PaO2<6.0 kPa
6-minute walk test<160m
Obvious chronic bronchitis, bronchiectasis or other infectious pulmonary diseases
More than 3 hospitalizations for pulmonary infection in the past 12 months before baseline assessment
Previous lobectomy, LVRS or lung transplantation
LVEF<45% and or RVSP>50mmHg
Anticoagulant therapy that cannot be stopped before surgery
Patients with obvious immune deficiency
Participated in other lung drug studies within the first 30 days of this study
Pulmonary nodules requiring intervention
Any disease or condition that interferes with the completion of the initial or subsequent assessment