Long-term Effects of Intensive Insulin Treatment in Type 1 Diabetes (SDIS)
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About
To investigate long-term effects on cardiovascular mortality/morbidity and renal failure in type 1 diabetes patients former randomized to intensive insulin treatment
Full description
The Stockholm Diabetes Intervention Study (SDIS) aimed to determine whether intensified insulin treatment were feasible and led to less serious diabetic complications. 102 patients with type 1 diabetes mellitus were randomized (October 1982 to March 1984) to intensified conventional treatment (ICT; n=48) or standard treatment (ST; n=54). The randomized SDIS study lasted for 7.5 years, whereas 96 patients were fully evaluated. Thereafter patients were assigned to their regular clinical visits.
In the present interventional study we wanted to study all-cause mortality and cardiovascular outcomes (i.e. myocardial infarction and stroke), and renal failure in the SDIS cohort until december 31 2011.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Born 1930 or later
- Type 1 diabetes
- Nonproliferative retinopathy
- Normal serum creatinine
- Unsatisfactory blood glucose control
Exclusion criteria
- Alcohol/drug abuse
- Proliferative retinopathy
Trial design
Primary purpose
Allocation
Interventional model
Masking
102 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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