Long-term Effects of Laser Refractive Surgery

Mayo Clinic

Status and phase: Completed; Phase 4

Conditions: Myopia

Treatments: Procedure: Laser Refractive Surgery

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00350246

66-04

Details and patient eligibility

About

This study will determine if there are short- and long-term postoperative differences in visual and corneal outcomes between different laser refractive surgical procedures.

Full description

We will measure postoperative differences in visual acuity, contrast sensitivity, corneal light scatter, density of keratocytes and subbasal nerves, corneal sensitivity, corneal topography and wavefront between PRK performed with epithelial removal by a laser or by a rotary brush and between LASIK performed by using a microkeratome or by using a femtosecond laser. Measurements will be made at baseline and at intervals over 5 postoperative years in 21 LASIK patients, 20 PRK patients, and 20 unoperated controls.

Enrollment: 62 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Myopia 1-10 diopters No other ocular abnormalities except presbyopia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)