Long-term Effects ReSet Your Mind - Mechanisms

Philipps University

Status: Completed

Conditions: Depression Mild; Depression Moderate

Treatments: Behavioral: Combination of Behavioral Activation and Mindfulness and Gratitude; Behavioral: Mindfulness and Gratitude; Behavioral: Behavioral Activation

Study type: Interventional

Funder types: Other

Identifiers

NCT06072209

ReSet your Mind - Mechanisms

Details and patient eligibility

About

See: ClinicalTrials.gov ID: NCT05402150

Relevant for this Paper:

This investigation aims to evaluate the stability of the effectiveness of different two-week online interventions in a four months follow-up regarding reward sensitivity, anhedonia and depression.

The authors will further investigate factors influencing treatment success regarding reward sensitivity. The investigators assume that the more depressive expectations and stress improve during our online intervention, the more change in reward insensitivity is experienced at follow-up. In addition, it is hypothesized that the more people engaged in physical activities and social encounters during the two-week online intervention, the more change in reward insensitivity is experienced at follow-up.

Full description

See for main study: ClinicalTrials.gov ID: NCT05402150.

A possible maintaining role in depressive symptoms plays reward hyposensitivity. Therefore, treatments should include evidence-based psychological interventions that target and modify reward insensitivity. Prior research lacks studies investigating reward sensitivity as main outcome measure, especially in the web-based format. This is why this study investigated an online intervention with the following groups regarding effectively increasing reward sensitivity compared to a waitlist control condition:

a) mindfulness-based interventions, b) behavioral activation, c) a combination of both.

The daily exercises were supported via videos and worksheets. Here, the investigators explore the effects after a four-months follow-up. In addition, this paper will deal with the long-term prediction of reward sensitivity, a feature not considered in our main paper preregistered with the ID NCT05402150. Factors, which are considered to play a big role in reward sensitivity are perceived stress, depressive expectations, physical activity and the frequency of social encounters.

Enrollment: 224 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 or above
• Fluent in German
• Informed consent
• Depressive symptoms (PHQ-9 > 5)

Exclusion criteria

• suicidality, severe depression
• current or lifetime: substance use disorder, psychotic disorders, bipolar I or II
• current psychotherapy
• if antidepressant medication: has not been stable over the last 4 weeks

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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224 participants in 4 patient groups

Behavioral Activation

Experimental group

Description:

14 days of daily excercises

Treatment:

Behavioral: Behavioral Activation

Mindfulness and Gratitude

Experimental group

Description:

14 days of daily excercises

Treatment:

Behavioral: Mindfulness and Gratitude

Combination: Behavioral Activation and Mindfulness and Gratitude

Experimental group

Description:

14 days of daily excercises

Treatment:

Behavioral: Combination of Behavioral Activation and Mindfulness and Gratitude

Waitlist control group

No Intervention group

Description:

Will receive the intervention (combination) after two weeks of intervention time of the other groups.