Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome

University of Aarhus

Status: Unknown

Conditions: Turner Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT00625001

1994/2424

Details and patient eligibility

About

Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS. The objective is therefore to describe longitudinal changes in BMD in TS.

The study is an observational follow-up study. Examinations at baseline, after 5 and 10 years.

Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover by bone markers.

Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.

Enrollment: 54 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Turner syndrome verified by karyotyping

Exclusion criteria

• untreated hypothyroidism or hyperthyroidism
• present or past malignant diseases
• clinical liver disease
• treatment with drugs known to interfere with bone metabolism (e.g. glucocorticoids)

Trial design

54 participants in 2 patient groups

1

Description:

Women with Turner syndrome

2

Description:

Healthy control women