Long-term Follow-up of Living Liver Donors: A Single-center Experience

Mansoura University

Status: Completed

Conditions: Liver Transplantation

Treatments: Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).

Study type: Observational

Funder types: Other

Identifiers

NCT04814290

No. MD/15.08.50

Details and patient eligibility

About

Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up.

Full description

Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up.

We used the 36-item short-form health survey (short form-36 health survey, version 1 [SF-36]). The scores for the 4 following subscales were higher in nondonors than in donors: physical functioning (P = 0.009), role limitations due to physical health (P = 0.002), energy/fatigue (P < 0.001), and bodily pain (P < 0.001). The scores on the 8 subscales of the SF-36 were higher in donors with living recipients than in donors whose recipients died (P < 0.001). Our results suggest that living donor right hepatectomy is safe and results in a postdonation HRQoL similar to that of nondonors in those donors whose recipients are healthy, while donors whose recipients die have a lower HRQoL that is significantly negatively correlated with the time since recipient death and improves over time.

Enrollment: 476 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-50 years
• no comorbidities.
• BMI less than 30 kg/m2.
• compatible ABO group.

Exclusion criteria

• Older than 50 years.
• Associated comorbidities.
• Obesity.
• Noncompatible ABO group.

Trial design

476 participants in 2 patient groups

living liver donors

Description:

cases already underwent hepatectomy for living-donor liver transplantation.

Treatment:

Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).

matched controls

Description:

healthy persons who attended the preoperative clinic while preparing for donation but were rejected because of an ABO blood group mismatch.

Treatment:

Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).