Long Term Follow up of the LTOG Cohort

University of Pennsylvania

Status: Invitation-only

Conditions: Lung Transplant Failure and Rejection

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04787822

834898

U01HL145435 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of the study is to follow participants who enrolled in the Lung Transplant Outcomes Group. Clinical data, functional assessments, and surveys will be collected to determine long term graft function and functional status of lung transplant recipients.

Full description

This project will involve both retrospective and prospective data collection from participants enrolled in the LTOG cohort studies. We will perform long-term Chronic Lung Allograft Dysfunction (CLAD) phenotyping of lung transplant recipients who participated in the LTOG cohort studies utilizing data collected for routine clinical visits. Surviving lung transplant recipients who participated in the LTOG cohort studies will be recruited to enroll in the longitudinal portion of the project. The longitudinal component will include follow-up data collection at 6 month intervals while alive until study termination, study withdrawal, or no longer being seen for follow-up at the participating center. Follow-up data collection will include clinical data collected by study coordinators by reviewing medical records, functional assessment through administration of the Short Physical Performance Battery (SPPB), blood collection and surveys. Data from this project will be linked to data and samples collected during the LTOG cohort or ancillary studies.

Enrollment: 4,000 estimated patients

Sex: All

Ages: 13+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

Long-term phenotyping of CLAD

• Lung transplant recipients who have previously enrolled in the LTOG cohort studies at one of the participating centers

Long-term functional status and well-being

• Lung transplant recipients who have previously enrolled in the LTOG cohort studies at one of the participating centers
• Alive

Exclusion Criteria

Long-term phenotyping of CLAD

• Lung transplant recipient not enrolled in LTOG cohort research studies

Long-term functional status and well-being

• Lung transplant recipient not enrolled in the LTOG cohort research studies
• Lung transplant recipient not receiving post-transplant follow-up care at a participating LTOG center