Long-term Oncologic Outcome of Breast-conserving Surgery in Breast Cancer Patients With BRCA1/2 Mutations

Hanyang University Seoul Hospital

Status: Completed

Conditions: Breast-conserving Surgery; BRCA1/2 Mutation

Treatments: Procedure: Breast-conserving surgery

Study type: Observational

Funder types: Other

Identifiers

NCT06429644

2022-04-039

Details and patient eligibility

About

The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients in breast cancer patients with BRCA 1/2 mutations.

Full description

The purpose of study is to assess the oncologic safety of BCS in patients carrying BRCA1/2 mutations by comparing long-term outcomes with mastectomy. The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients. By providing insights into the feasibility of BCS for patients with BRCA1/2 mutations, the investigators aim to present evidence to aid in surgical decision-making for the care of these patients.

Enrollment: 4,010 patients

Sex: Female

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary invasive breast cancer who underwent BCS or mastectomy
• Received a BRCA1/2 mutation test

Exclusion criteria

• Patients with de novo metastasis
• Pregnancy-associated breast cancer

Trial design

4,010 participants in 13 patient groups

Dongtan Sacred Heart Hospital

Description:

Department of Surgery, Dongtan Sacred Heart Hospital, Hallym University, Dongtan, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Samsung Medical Center

Description:

Division of Breast Surgery, Department of Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Seoul National University Hospital

Description:

Breast Care Center, Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Severance hospital

Description:

Department of Surgery, Severance hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Kyungpook National University Chilgok Hospital

Description:

Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Gangnam Severance Hospital

Description:

Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Hanyang University Medical Center

Description:

Department of Surgery, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Hallym University Sacred Heart Hospital

Description:

Department of Breast \& Endocrine Surgery, Hallym University Sacred Heart Hospital, Hallym University, Anyang, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Kangbuk Samsung Hospital

Description:

Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Incheon St. Mary's Hospital

Description:

Department of Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Kyung Hee University Hospital

Description:

Department of Surgery, Kyung Hee University Hospital, Seoul, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Keimyung University School of Medicine

Description:

Department of Surgery, Keimyung University School of Medicine, Daegu, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery

Asan Medical Center

Description:

Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Treatment:

Procedure: Breast-conserving surgery