Long-term-opioid-free Anesthesia in Anterior Cervical Surgery

Sichuan University

Status: Completed

Conditions: Long-term-opioid-free Anesthesia

Treatments: Drug: Remifentanil Hydrochloride; Drug: Sufentanil Citrate

Study type: Interventional

Funder types: Other

Identifiers

NCT05548465

WCH20220916

Details and patient eligibility

About

We design this randomized controlled trial to explore the safety and efficacy of the long-term-opioid-free anesthesia in anterior cervical surgery, to reduce the dosage of perioperative long-acting opioids and promoting patients'rehabilitation.

Enrollment: 100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing anterior cervical surgery., sign the "informed consent form"
• Age above 18 years old
• ASA Ⅰ-Ⅲ.

Exclusion criteria

• Pregnant or lactating women.
• Patients with history of drug abuse, including but not limited to opioids, amphetamines, ketamine, etc
• Allergic to the materials or drugs used in this study.
• Patients with current/previous gastrointestinal bleeding and gastric ulcers;
• Have history of nervous system diseases such as peripheral neuropathy, or psychiatric mental illness.
• Other conditions that the investigators consider unsuitable for participation in the study, such as deaf, Parkinson's disease, and difficult to communication etc.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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100 participants in 2 patient groups

Long-term-opioid-free anesthesia group.

Experimental group

Treatment:

Drug: Remifentanil Hydrochloride

Long-term-opioid anesthesia group.

Active Comparator group

Treatment:

Drug: Sufentanil Citrate