Long-term Outcome of General Anesthesia on Dysgnosia (LOGAND)

Nanjing Medical University

Status and phase: Unknown; Phase 4

Conditions: Delirium,; Amnestic,; Dementia,; Cognitive Disorders

Treatments: Drug: Propofol; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01184638

NJFY7M12

NJMU-2010-07022

Details and patient eligibility

About

Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.

Enrollment: 10,000 estimated patients

Sex: All

Ages: 10 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with informed consents
• Without basal disorders of neurology and psychiatrics

Exclusion criteria

• With the history of cognitive disorders
• With chronic neurological disorders
• Cannot communicate with investigators
• Cannot stand general anesthesia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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10,000 participants in 3 patient groups

Local anesthesia

No Intervention group

Description:

Patients received local anesthesia without any intervention of general anesthetics

Inhalational anesthesia

Active Comparator group

Description:

Patients received sevoflurane anesthesia during general anesthesia

Treatment:

Drug: Sevoflurane

Intravenous anesthesia

Active Comparator group

Description:

Patients received intravenous anesthetic (Propofol) during general anesthesia

Treatment:

Drug: Propofol