Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer

Mass General Brigham

Status: Unknown

Conditions: Prostate Cancer

Treatments: Radiation: brachytherapy

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT00681694

01-264

Details and patient eligibility

About

The purpose of this research study is to assess outcomes of treatment for early prostate cancer. Current treatments for early (non-metastatic) cancer may cause long-term impairments in the patients quality of life. In this study we will compare the outcomes of patients treated with two alternative brachytherapy (seed implants) techniques using a series of questionnaires.

Full description

Participants will be asked to complete a questionnaire about their health prior to treatment, at 1, 3 and 12 months after treatment and then once a year 4 more times.

Enrollment: 414 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pathological diagnosis of an adenocarcinoma of the prostate
• 18 years of age or older
• Prior choice of either standard brachytherapy or MRIGPB as primary treatment

Exclusion criteria

• Prior primary therapy (surgery or external beam radiation) for prostate cancer
• Current hormone ablation therapy

Trial design

414 participants in 3 patient groups

MRBT

Description:

MRI-assisted brachytherapy, the experimental arm

Treatment:

Radiation: brachytherapy

Radiation: brachytherapy

Radiation: brachytherapy

USBT1

Description:

Standard ultrasound-guided brachytherapy performed by group 1 (control arm 1)

Treatment:

Radiation: brachytherapy

Radiation: brachytherapy

Radiation: brachytherapy

USBT2

Description:

Standard ultrasound-guided brachytherapy performed by group 2 (control group 2)

Treatment:

Radiation: brachytherapy

Radiation: brachytherapy

Radiation: brachytherapy