Long-term Outcomes of Duodenal Adenocarcinoma From a Large Cohort

Nanfang Hospital, Southern Medical University

Status: Not yet enrolling

Conditions: Gastrointestinal Disease

Treatments: Procedure: Radical operation and perioperative therapy

Study type: Observational

Funder types: Other

Identifiers

NCT06443086

NFEC-2024-171

Details and patient eligibility

About

The investigators will conducted a hospital-based cohort study in our 15-year experience with DA aimed at investigating the long-term outcomes of the patients with DA, along with analyzing the impact of the tumor characteristics, operations and adjuvant therapy on survival outcomes.

Full description

Numerous meta-analyses and systematic reviews have delved into the treatment of DA, yet the majority of the studies retrospective, single-center, and small sample size series, particularly in China. To bridge this knowledge gap, the investigators will conduct a hospital-based cohort study designed to investigate the long-term survival outcomes of the participants with the non-ampulla duodenal adenocarcinoma, and the effects of tumor characteristics, surgery, and adjuvant therapy on survival outcomes.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

(1) histologically confirmed non-ampulla DA;

Exclusion criteria

1. had other gastrointestinal cancer;
2. had incomplete medical records, or lost follow-up shortly after diagnosis;
3. refused clinical data collection.

Trial design

400 participants in 1 patient group

Duodenal carcinoma patients

Description:

The patients included in this study were drawn from a hospital-based cohort and included cases diagnosed and treated at the facility. Inclusion criteria were histologically confirmed non-ampulla DA, including all stages of disease at diagnosis. Patients were excluded if they had ampulla cancer or other forms of gastrointestinal cancer, had incomplete medical records, or lost follow-up shortly after diagnosis. This rigorous selection process ensured the homogeneity of the study population and the relevance of the findings to non-ampulla DA.

Treatment:

Procedure: Radical operation and perioperative therapy