Long-Term Outcomes of Hypopituitarism Following Gamma Knife Radiosurgery for Pituitary Adenomas

Al-Azhar University

Status: Completed

Conditions: Pituitary Adenomas; Gamma Knife Radiosurgery; Long Term; Hypopituitarism

Treatments: Procedure: Gamma Knife Radiosurgery

Study type: Observational

Funder types: Other

Identifiers

NCT07015645

DFM-IRB 00012367-25-05-006

Details and patient eligibility

About

This study aims to assess long-term outcomes of hypopituitarism following gamma knife radiosurgery (GKRS) for pituitary adenomas.

Full description

Pituitary adenomas (PAs) are one of the most common intracranial neoplasms, accounting for 10-20% of diagnosed brain tumors.

Initial gamma knife radiosurgery (GKRS) can be an alternative treatment for selected NFPA patients with comorbidities, documented growth small tumors, cavernous sinus invasion, or advanced age.

Hypopituitarism is one of the most common complications of radiosurgery (Cordeiro et al., 2018). Long-term follow-up is crucial to assess new pituitary deficits. Typically, hypopituitarism presents within the first 2-4 years after the treatment with radiosurgery, but the risk of pituitary insufficiency increases to up to 80%. Reports on the highest incidence of new-onset hypopituitarism also mentioned the longest follow-up period.

Enrollment: 137 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years.
• Both sexes.
• Patients treated with gamma knife radiosurgery (GKRS).

Exclusion criteria

• Patients with inadequate endocrine follow-up (<12 months).
• Patients who had undergone previous radiation therapy.
• Pituitary insufficiency which presents before gamma knife radiosurgery (GKRS).
• Patients without visible glands.

Trial design

137 participants in 1 patient group

Pituitary Adenomas group

Description:

Patients received gamma knife radiosurgery (GKRS) treatment for pituitary adenomas.

Treatment:

Procedure: Gamma Knife Radiosurgery