Long Term Results of Surgical and Percutaneous Double Orefices Mitral Repair in Patient With p2 Prolapse Causing Degenerative Mitral Regurgitation

Michele De Bonis

Status: Completed

Conditions: Degenerative Mitral Valve Disease; Mitral Regurgitation

Treatments: Procedure: Central edge-to-edge

Study type: Observational

Funder types: Other

Identifiers

NCT05836532

LORD-P2_DMR

Details and patient eligibility

About

Mitral regurgitation is a pathology affecting the left atrioventricular valve that causes a volumetric and pressure overload in the left chambers due to the loss of unidirectionality normally guaranteed by the cardiac valve system. The gold standard for severe mitral regurgitation is currently mitral valve plastic surgery.

Edge to edge, on the other hand, allows shorter CEC and aortic clamping times and does not require significant surgical experience in the field of mitral valve repair, therefore edge to edge could be an excellent strategy in patients suffering from mitral regurgitation caused by P2 prolapse when quadrangular resection cannot be performed.

The main objective of the present study is to examine the medium to long-term outcomes (in terms of survival and plastic outcomes) of patients undergoing central edge-to-edge to treat posterior flap pathology (P2).

Enrollment: 110 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mitral regurgitation with degenerative etiology
• Mitral pathology exclusively dependent on P2
• Surgical creation of a double mitral valve orifice with or without a ring as the only mitral valve repair technique.

Exclusion criteria

• Other mitral regurgitation etiologies (eg. functional, radiation-induced, rheumatic...)