Long-Term SafEty and Clinical Outcomes of LivmArli in Patients in the United States (LEAP-US)

Mirum Pharmaceuticals

Status: Enrolling

Conditions: Progressive Familial Intrahepatic Cholestasis; Alagille Syndrome

Treatments: Drug: Livmarli; Drug: Livmarli

Study type: Observational

Funder types: Industry

Identifiers

NCT06193928

MRX-310

Details and patient eligibility

About

The objective of this 5-year, prospective, observational cohort study is to evaluate the long-term safety and clinical outcomes of patients with Alagille syndrome (ALGS) or Progressive familial intrahepatic cholestasis (PFIC) treated with Livmarli.

Full description

Livmarli® is a novel, minimally absorbed, pharmacological product that inhibits the ileal bile acid transporter (IBAT) in the terminal ileum, leading to reduced levels of bile acids. Livmarli (maralixibat) has been developed by Mirum Pharmaceuticals and was the first treatment approved by the US Food and Drug Administration (FDA) for the treatment of cholestatic pruritus in patients 3 months of age and older with Alagille syndrome (ALGS). Subsequently, Livmarli was approved by the FDA for the treatment of cholestatic pruritus in patients 12 months of age and older with Progressive familial intrahepatic cholestasis (PFIC). To be eligible for the study, participants must meet the following criteria:

• A clinically and/or genetically confirmed ALGS diagnosis or PFIC diagnosis
• Prescribed Livmarli

Enrollment: 70 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• A clinically and/or genetically confirmed ALGS diagnosis or PFIC diagnosis
• Participant prescribed Livmarli

Exclusion criteria

• Refusal to provide informed consent/assent (if required by the local IRB)
• Previously or currently on Livmarli through participation in a clinical study or expanded access program
• Participants who have previously received an SBD or LT
• Any condition or abnormalities that, in the opinion of the investigator, may interfere with the participant participating in or completing the study
• Participants who have received an investigational drug within 30 days of the first dose of Livmarli

Trial design

70 participants in 2 patient groups

Alagille syndrome (ALGS)

Description:

* A clinically and/or genetically confirmed ALGS diagnosis * Participant prescribed Livmarli

Treatment:

Drug: Livmarli

Drug: Livmarli

Progressive familial intrahepatic cholestasis (PFIC)

Description:

* A clinically and/or genetically confirmed PFIC diagnosis * Prescribed Livmarli

Treatment:

Drug: Livmarli

Drug: Livmarli