Long-term Use of Viltolarsen in Boys With Duchenne Muscular Dystrophy in Clinical Practice (VILT-502)

NS Pharma

Status and phase: Active, not recruiting; Phase 4

Conditions: Duchenne Muscular Dystrophy

Treatments: Drug: Viltolarsen

Study type: Interventional

Funder types: Industry

Identifiers

NCT04687020

VILT-502

Details and patient eligibility

About

The VILT-502 study is Non-interventional Study(United States)/Low-intervention Clinical Trial (Canada) of Viltolarsen administered intravenously once weekly for 10 years to boys with DMD who complete the NS-065/NCNP-01-202 study.

Full description

The VILT-502 study is an open-label, single-arm study to assess the long-term safety and effectiveness of viltolarsen, an exon skipping therapy for the treatment of DMD. Patients who complete the Phase II long-term extension study and meet the additional inclusion and exclusion criteria of the present protocol will be invited to enroll. Viltolarsen will be administered through weekly IV infusions, at the study site or at home.

The VILT-502 study will be conducted as a non-interventional study in the US, and as a low-intervention clinical trial in Canada where viltolarsen is not yet commercially available, owing to differences in the stage of regulatory approval in the two countries.

Enrollment: 9 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patient, patient's parent or legal guardian have provided written informed consent/medical record release authorization prior to any extension study-specific procedures, and the patient has provided assent appropriate for his age and developmental status.
2. Patient completed the NS-065/NCNP-01-202 study and was judged by the investigator as appropriate to participate in the VILT-502 study.
3. Patient and parent or legal guardian are willing and able to comply with scheduled visits, study treatment administration plan, and study procedures.

Exclusion criteria

1. Patient has an allergy or hypersensitivity to the study drug or to any of its constituents.
2. Patient has severe behavioral or cognitive problems that preclude participation in the study, in the opinion of the investigator.
3. Patient has previous or ongoing medical condition, medical history, physical findings or laboratory abnormalities that could affect safety, make it unlikely that treatment and observation will be correctly completed or impair the assessment of study results, in the opinion of the investigator.
4. Patient had a treatment which was made for the purpose of dystrophin or its related protein induction after completing the NS-065/NCNP-01-202 study.
5. Patient took any other investigational drugs after completing the NS-065/NCNP-01-202 study.
6. Patient plans to participate in another clinical trial.
7. Patient was judged by the investigator and/or the Sponsor as not appropriate to participate in the study for reasons other than #1 - #6 above.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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9 participants in 1 patient group

Non-interventional (United States) / Low-interventional (Canada) : Viltolarsen

Other group

Description:

Patients will receive viltolarsen (recommended dose 80mg/kg/week) during a treatment period up to 120 months.

Treatment:

Drug: Viltolarsen