Long Term Vascular Changes in Type 1 Diabetes (DM09)

University of Oslo (UIO)

Status: Completed

Conditions: Diabetes Mellitus, Type 1; Coronary Heart Disease; Complications

Study type: Observational

Funder types: Other

Identifiers

NCT00991575

916501

S-08843c/21262

Details and patient eligibility

About

The main purpose of this study is to investigate progression of late complications of diabetes during the last ten years in a well characterized cohort of type 1 diabetes with a long duration of the disease, and to define factors responsible for the progression of late complications.

Full description

Despite intensively research in the field of hyperglycaemia and coronary heart disease in type 1 diabetes it is still not known in detail how hyperglycaemia leads to damage of the vessels.

The aims of the present proposal are therefore two-fold:

1. To study in detail the progression of atherosclerosis (and micro vascular complications) in a well characterized cohort of type 1 diabetes with a long duration of the disease. This project will be a continuation of the Oslo study, a cohort started in 1982, with the last follow-up study in 1999/2000.
2. To define factors responsible for the progression of coronary heart disease (and micro vascular complications) in this cohort.

Enrollment: 33 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

The original criteria from 1982:

Inclusion Criteria:

• Age 18-45 years
• Diagnosis of type 1 diabetes at < 30 years of age, disease duration > 7 but < 30 years
• C-peptide < 0, 1 nmol/l

Exclusion Criteria:

• Serum creatinine > 150 µmol/l
• Diastolic blood pressure <100mmHg
• Overt nephropathy
• Proliferative retinopathy
• Pregnancy
• A history of neuropathy
• Other chronical disease
• Treatment with other drugs except insulin and oral contraceptives

Trial design

33 participants in 1 patient group

Diabetes, type 1