Longevity Families of the Netherlands (LOF-NL)

Leiden University Medical Center (LUMC)

Status: Enrolling

Conditions: Aging; Extreme Longevity; Longevity; Familial Longevity

Study type: Observational

Funder types: Other

Identifiers

NCT06374069

NL81887.058.23

Details and patient eligibility

About

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.

The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.

Enrollment: 600 estimated patients

Sex: All

Ages: 75+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
• Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity

Exclusion criteria

Trial design

600 participants in 2 patient groups

Cases - Enriched for familial longevity

Description:

Siblings of dutch Caucasian descent ages 75 and older

Controls - Non-enriched for familial longevity

Description:

Individuals of dutch Caucasian descent ages 75 and older solely in their family.