Longitudinal Acute Air Pollution Systemic Effects (LAPSE)

Umeå University

Status: Completed

Conditions: Healthy

Treatments: Other: Filtered air; Other: Diesel Exhaust

Study type: Interventional

Funder types: Other

Identifiers

NCT02677662

2015-69-31M

Details and patient eligibility

About

Air pollution continues to be a key global issue with many governments focusing great attention on air quality legislation because of its harmful environmental and health impacts. Whilst there is much that remains unknown about the mechanisms underlying the negative health effects of air pollution, it is generally acknowledged that air pollution exposure leads to an increase in cardiovascular, cerebrovascular and respiratory mortality and morbidity. The current study will investigate systemic effects during a 72 hour period after a controlled diesel exhaust exposure.

Full description

Exposure to air pollution (both indoor and outdoor sources) contributes to the premature deaths of 7 million people each year, primarily linked to cardiovascular and respiratory conditions. Within the complex mixture which air pollution comprises, combustion derived particulate matter (PM) has been suggested as one of the most harmful components to the cardiopulmonary system. In urban areas PM derived from combustion originates largely from diesel vehicles.

Numerous experimental chamber studies have demonstrated respiratory as well as cardiovascular dysfunctions after the inhalation of diesel exhaust. Many of these dysfunctions are driven by inflammation and oxidative stress. There is much less knowledge concerning the systemic effects of diesel exhaust exposure, and especially over longer time courses than 24 hours.

The investigators aim to investigate the time course of systemic effects (such as markers of inflammation, cardiovascular dysfunction, and oxidative stress) in blood and urine samples taken after a diesel exhaust exposure. The effects of exercise or rest in an experimental chamber exposure will also be investigated.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal clinical examination
• Normal EKG
• Normal routine blood tests
• Normal lung function
• Normal skinprick test

Exclusion criteria

• Cardiovascular disease
• Diabetes Mellitus
• Asthma and/or allergy
• Smoking

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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30 participants in 2 patient groups

Filtered air exposure

Sham Comparator group

Description:

2 hour exposure to filtered air during intermittent exercise or rest.

Treatment:

Other: Filtered air

Diesel exhaust exposure

Experimental group

Description:

2 hour exposure to dilute diesel exhaust (approximate PM10 (particulate matter\<10um) concentration 300 mcg/m3) during intermittent exercise or rest.

Treatment:

Other: Diesel Exhaust