Longitudinal and Biological Study of Childhood Disintegrative Disorder

United States Department of Health and Human Services (HHS)

Status: Terminated

Conditions: Pervasive Child Development Disorders; Autism

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00004458

YALE-5P01HD0300830

199/13682

YALE-HIC-5895

Details and patient eligibility

About

OBJECTIVES:

I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays.

II. Collect data on molecular genetics of proband and family members.

Full description

PROTOCOL OUTLINE:

Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist

An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

Sex: All

Ages: 2 to 9 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Psychologically diagnosed (DSM-IV) as Childhood Disintegrative Disorder
• No known genetic or medical syndrome (Down syndrome or cerebral palsy)
• Must speak English