Longitudinal Assessment of Protein Markers in the Cerebrospinal Fluid of Patients With Central Nervous System Involvement (HJ-COLOCS)

Imagine Institute

Status

Begins enrollment this month

Conditions

Central Nervous System Diseases

Neurologic Disorder

Study type

Observational

Funder types

Other

Identifiers

NCT07313098

HJ-23-HJ-COLOCS

Details and patient eligibility

About

In the context of adult pathology, research into biomarkers in cerebrospinal fluid (CSF) has already identified proteins that are commonly used for the early diagnosis of certain neurodegenerative diseases. However, the lack of data available in the literature on pediatric diseases has limited the use of biomarkers in routine practice in children. Importantly, our group has pioneered the establishment of CSF biomarkers in children (e.g., measurement of interferon alpha in CSF by ultra-sensitive digital ELISA), which will undoubtedly be used in routine clinical practice in the future. In light of these arguments, the establishment of a CSF biobank will have major clinical implications, given the rarity of the diseases treated and the number of patients followed.

Enrollment

1,000 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with a neurological condition diagnosed by a physician requiring cerebrospinal fluid (CSF) collection, through:
- Neurosurgical procedure (EVD, VP shunt, VSG shunt, tumor surgery, spinal surgery with dural opening, ELD);
- Lumbar puncture (LP).
Patients who have (or whose legal guardians, where applicable, have) consented to the storage and reuse of residual biological samples collected during the course of care within the biological collection.

Exclusion criteria

1. Objection by the patient and/or the legal guardian, if the patient is a minor, to participation in the study.