Longitudinal Changes of Brain Functional Connectivity in Migraine

Samsung Medical Center

Status: Unknown

Conditions: Migraine

Treatments: Diagnostic Test: resting-state functional MRI

Study type: Observational

Funder types: Other

Identifiers

NCT03487978

2017-03-113

Details and patient eligibility

About

The purpose of this study is to identify a core fMRI feature that determines migrainous brain and plastic fMRI features that changes with longitudinal courses of migraine.

Full description

Migraine is associated with functional alterations in specific brain networks. The investigators aimed to identify network abnormalities which remain unchanged throughout the longitudinal course of migraine. The investigators also aimed to identify networks which change in association with changes in migraine frequency and associated psychiatric conditions. The investigators expect these can serve as neuroimaging biomarkers for diagnosis of migraine brain and monitoring of disease severity.

Enrollment: 100 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Migrainuers :

1. age 18-50 years
2. migraine with or without aura as defined by the third edition of the International Classification of Headache Disorders (ICHD-3 beta)
3. if female, before the onset of menopausal

Controls:

1. age 18-50 years
2. no headache disorder other than Infrequent episodic tension-type headache as defined by the ICHD-3 beta

Exclusion criteria

1. contraindicated to MRI
2. pregnancy
3. require sedation treatment because of claustrophobia when performing MRI
4. predicted to be unable to write the headache diary due to cognitive decline
5. refuse study procedure

Trial design

100 participants in 2 patient groups

Migraineurs

Description:

Patients diagnosed with migraine based on the ICHD-3 beta will undergo 3-tesla resting-state functional MRI.

Treatment:

Diagnostic Test: resting-state functional MRI

Control

Description:

Normal controls without headaches will undergo 3-tesla resting-state functional MRI.

Treatment:

Diagnostic Test: resting-state functional MRI