Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders

Mount Sinai Health System

Status: Invitation-only

Conditions: Demyelinating Autoimmune Diseases, CNS; Neuromyelitis Optica; Multiple Sclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT05982925

STUDY-21-01855

Details and patient eligibility

About

In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic mechanisms, and clinical implications of central nervous system (CNS) lesions, in particular lesions in the cerebral cortex, in multiple sclerosis (MS) and other inflammatory and autoimmune disorders affecting the CNS. Patients with these disorders, as well as healthy controls, will undergo baseline clinical evaluation and testing, bloodwork, and MRI, with follow up clinical evaluation, bloodwork, and MRI at years 1, 3, and 6. Additional MRIs may be performed in patients with possible new lesion formation or to compare MRI techniques. Lumbar puncture will be performed on participants who are not currently being treated with disease modifying therapies and who are willing to undergo the procedure.

Enrollment: 170 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years old
• able to provide consent in English
• able to undergo MRI

Exclusion criteria

• contraindication to MRI
• pregnancy

Trial design

170 participants in 3 patient groups

MS Participant

Description:

Adults with multiple sclerosis

Control Participant

Description:

Adults without neurologic disease

Other Neuroinflammatory Participants

Description:

Adults with a neuroinflammatory disease that is not multiple sclerosis