Longitudinal Dynamics of AT1R Antibodies in Kidney Transplant Recipients

Seoul National University

Status: Completed

Conditions: Kidney Transplantation; Graft Survival; Angiotensin II Type 1 Receptor Antibody

Study type: Observational

Funder types: Other

Identifiers

NCT07374484

AT1R Antibodies in KT

RS-2023-KH140187 (Other Grant/Funding Number)

Details and patient eligibility

About

This study aims to investigate the dynamics of Angiotensin II Type 1 Receptor Antibodies (AT1R-Ab) before and after kidney transplantation. The purpose is to understand how changes in AT1R-Ab levels may impact post-transplant kidney function and graft survival. Participants will include kidney transplant recipients, and their AT1R-Ab levels will be monitored over a one-year period. This research may help develop better predictive models for transplant outcomes, improving clinical decision-making for transplant physicians.

Full description

The study will be conducted as a prospective cohort study involving kidney transplant recipients. The participants will undergo monitoring of their AT1R-Ab levels at multiple time points before and after the transplantation, including 2 weeks, 3 months, and 1 year post-transplant. Data collected will include clinical information such as kidney function tests, graft survival rates, and post-transplant complications. The study will aim to correlate AT1R-Ab dynamics with clinical outcomes such as delayed graft function (DGF), graft loss, and creatinine levels.

Enrollment: 241 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Eligible patients were those who had serum samples collected at pre-transplant and at 2 weeks, 3 months, and 1-year post-transplant, with a minimum follow-up of 1 year

Exclusion criteria

Exclusion criteria were simultaneous multi-organ transplantation and age younger than 18 years.

Trial design