Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors

Zhejiang University

Status: Enrolling

Conditions: Living Donor Liver Transplantation Recipients; Deceased Donor Liver Transplantation Recipients; Living Liver Donor

Treatments: Procedure: Living Donor Hepatectomy; Procedure: liver transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT07301853

2025-0793

Details and patient eligibility

About

This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors. By collecting comprehensive clinical data and conducting systematic long-term follow-up, the researchers intend to establish a specialized, standardized, and individualized follow-up management system. The ultimate goal is to optimize intervention strategies and improve patient prognosis and quality of life for both recipients and donors.

Enrollment: 9,999 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients undergoing liver transplantation or living donor hepatectomy at the study center (living donor should be approved by the hospital ethics committee for living organ donation);
2. Age 18 years or older;
3. Willing to participate in the long-term follow-up management program;
4. Signed informed consent form;

Exclusion criteria

1. Patients undergoing combined organ transplantation
2. Patients with severe mental illness or cognitive impairment who are unable to cooperate with follow-up assessments.
3. Donors whose surgery is aborted intraoperatively for any reason.
4. Unable or unwilling to comply with the long-term follow-up schedule.

Trial design

9,999 participants in 2 patient groups

recipients

Description:

A patient who received a new, healthy liver (or part of one from a living donor) to replace their own diseased liver

Treatment:

Procedure: liver transplantation

living donors

Description:

A healthy person who donated a portion of their healthy liver to someone with liver failure.

Treatment:

Procedure: Living Donor Hepatectomy