Longitudinal Follow-up of Brown Adipose Tissue Function and Structure (BATFollowUp)

Turku University Hospital (TYKS)

Status: Completed

Conditions: Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT01985503

BAT-Follow-Up

BATFOLLOWUP (Other Identifier)

Details and patient eligibility

About

In Turku PET Centre, there have been 3 positron emission tomography studies on brown adipose tissue (BAT) activity in healthy adults. BATPET was performed between 2008 and 2009. FATBAT started in 2011 and Dixon-BAT in 2012 and they are both currently ongoing. In the current study, participants of BATPET, FATBAT and Dixon-BAT studies are recruited for a follow-up study to examine associations between obesity, cardiovascular risk factors, serum metabolic profile and BAT structure at baseline and during follow-up several years later. 43 BATPET participants will be called for follow-up in 2013 with a follow-up period of 5 years and 52 FATBAT and Dixon-BAT participants in years 2014 and 2015 with a follow-up period of 3 years. The aim of this study is to examine longitudinal associations between BAT function and structure, liver adiposity and cardiovascular risk factors at baseline and during follow-up.

Enrollment: 95 estimated patients

Sex: All

Ages: 22 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All study subjects have been screened prior to acceptance in BATPET, FATBAT and Dixon-BAT studies and no screening for inclusion is required in the current study.

Exclusion criteria

• 1. Smoking 2) Blood pressure > 160/100 mmHg 3) Pregnancy or lactation 4) Medication (expected effect on study variables)

Trial design

95 participants in 2 patient groups

Phase 1 group

Description:

Subjects were studied in 2009 and their follow-up is in 2014.

Phase 2 group

Description:

Subjects were studied in 2011 and their follow-up is in 2016.