Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

Yonsei University

Status: Completed

Conditions: Overweight and Obesity

Treatments: Genetic: rs662799 (APOA5 -1131T>C)

Study type: Observational

Funder types: Other

Identifiers

NCT03367598

PA_fu_APOA5_rs662799

Details and patient eligibility

About

The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

Enrollment: 503 patients

Sex: All

Ages: 30 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Nondiabetic (fasting serum glucose concentration < 126 mg/dL)
• Nonobese (BMI ≥ 25 kg/m2)

Exclusion criteria

• Current and/or past history of cardiovascular disease
• Diabetes mellitus (fasting glucose levels ≥126 mg/dL)
• Abnormal liver or renal function
• Thyroid or pituitary disease
• Pregnancy or lactation
• Regular use of any medication

Trial design

503 participants in 2 patient groups

Normal weight

Description:

nondiabetic and nonobese individuals (18.5 kg/m2 ≤ BMI \< 25 kg/m2, n=349)

Treatment:

Genetic: rs662799 (APOA5 -1131T>C)

Overweight

Description:

nondiabetic and nonobese individuals (25 kg/m2 ≤ BMI \< 30 kg/m2, n=154)

Treatment:

Genetic: rs662799 (APOA5 -1131T>C)