LONGitudinal Multi-omics Phenotyping of KIDney Function Alteration

Charité University Medicine Berlin

Status: Enrolling

Conditions: Chronic Kidney Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT05570929

LONGKID

Details and patient eligibility

About

This is a longitudinal observation of kidney function, immune system and gut microbiota before and 24 weeks after a live kidney transplantation conducted in donor and recipient pairs living in the same household. Outcome measures include kidney function, body composition, blood pressure, gut microbiome composition, metabolomics and immune cell states.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body-Mass-Index 18,5 - 34,9 kg/m2
• Planned living kidney donation / transplantation

Exclusion criteria

• Clinically relevant heart, lung, liver, and kidney diseases
• Postoperative phase
• Acute infections
• Vegan diet
• Change of body weight of more than 10% in the month prior to study entry
• Known drug or alcohol abuse

Trial design

20 participants in 2 patient groups

Kidney Donor

Description:

Defined as a human individual donating a kidney

Kidney Recipient

Description:

Defined as a patient suffering from chronic kidney disease being the recipient of a kidney transplant