Looking for a Blood Epigenetic Signature to Predict Female Infertility (FIB_CARIPLO)

Università Vita-Salute San Raffaele

Status: Enrolling

Conditions: Female Infertility

Treatments: Genetic: search for epigenetic profile of infertility

Study type: Observational

Funder types: Other

Identifiers

NCT06098495

FIB_CARIPLO_1.0

Details and patient eligibility

About

The present research project aims to study the DNAm mechanisms underlying the reduction of fertility due to the progressive depletion of oocyte quality. Specifically, our project aims to build an epigenetic clock for MGCs by using outcomes that are certainly related to female fertility. The validation of such findings will be carried out on peripheral blood in order to guarantee its non-invasiveness and allow for any clinical transferability. In order to identify a blood epigenetic signature able to predict female infertility, we planned to explore the problem from different points of view by conducting several studies in different settings.

Enrollment: 1,456 estimated patients

Sex: Female

Ages: 18 to 43 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18< age <43, Infertile woman undergoing ART, recurrent pregnancy loss

Exclusion criteria

• age < 18 or > 44, previous ovarian surgery, severe male factor infertility

Trial design

1,456 participants in 4 patient groups

infertile women (unexplained, tubal, mild male factor)

Description:

women belonging to couples selected for homologous IVF due to an unexplained, tubal or mild male factor

fertile women

Description:

women without any infertility history who are attempting to conceive naturally

Treatment:

Genetic: search for epigenetic profile of infertility

infertile women (ovarian factor)

Description:

women selected for homologous IVF for different reason og chohort 1

Treatment:

Genetic: search for epigenetic profile of infertility

recurrent pregnancy loss

Description:

women affected by idiopathic recurrent pregnancy loss

Treatment:

Genetic: search for epigenetic profile of infertility