Lopinavir Capsules to Kaletra or Invirase Tablets (LoCKIT)

Royal Free Hampstead NHS Trust

Status and phase

Completed

Phase 4

Conditions

HIV Infections

Treatments

Drug: Lopinavir/ritonavir (Kaletra®)

Drug: Saquinavir (Invirase®)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00438152

MV20507

Details and patient eligibility

About

This study will compare the benefit for patients switching from Kaletra® to Invirase® tablets over remaining on Kaletra® (based on randomization), to elicit the lipid benefits inferred in previous studies

Full description

This is a prospective, phase IV, multicentre, randomised, open-label, 2-arm, 24-week study. Approximately 130 HIV-1 infected patients on a stable antiretroviral regimen containing Kaletra® with 2 nucleoside/nucleotide analogues will be randomized to 1 of 2 treatment arms: saquinavir with ritonavir 1000/100 mg BID (using Invirase® tablets) or lopinavir/ritonavir 400/100 mg BID (using Kaletra® tablets).Eligibility for enrollment will be determined at a screening visit that will occur within 30 days of the baseline visit. Protocol-defined study assessments will take place at clinic visits at the end of Weeks 4, 12, and 24.

Enrollment

53 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male or non-pregnant, non-nursing females >18 years of age
Seropositive for HIV-1
On an antiretroviral combination of Kaletra® with 2 nucleoside/nucleotide analogues for at least 6 months
HIV-1 RNA viral load <50 copies/mL (2 consecutive measurements in the prior 6 months) plus screening viral load <50 copies/ml.
Ability and willingness to provide written informed consent and adhere to the study regimen
Females of childbearing potential must have a documented negative serum or urine pregnancy test at screening/baseline and ensure that 2 reliable forms of contraception are being used, including a barrier method, for the duration of the study and for 90 days after the last dose of study medication

Exclusion criteria

Documented virological failure on a protease inhibitor ARV regimen prior to commencing Kaletra® regimen
Documented protease mutation (one or more from the following list) prior to commencing Kaletra® regimen:
M46I/L/V, I47A/V, G48V/M, I50V, F53L/Y, I54L/M/V/A/T/S, V82A/T/S/F/M/L, I84A/V/C, L90M
Patients with acute hepatitis B or C infection
Females who are pregnant, breast-feeding, or who plan to become pregnant or breast-feed during the study·
Significant renal dysfunction (creatinine clearance [CrCl] <60 mL/min) and/or hepatic impairment (aspartate aminotransferase/alanine aminotransferase [AST/ALT] >3 X ULN and/or documented liver cirrhosis)

Note: The site will calculate each patient's CrCl using the Cockcroft-Gault formula [28] as shown below:

CrCl = [140 - age (yr)] × weight (kg) × constant 72 × serum creatinine (Cr) (mg/dL) where, constant = 1 for men and 0.85 for women

Any current known clinical or laboratory parameter of ACTG Grade 4 (see Appendix 4). However, asymptomatic Grade 4 abnormalities will be permitted at the discretion of the investigator if deemed clinically appropriate. Abnormalities deemed insignificant by the investigator must be discussed with the sponsor prior to enrollment.
Evidence of active, untreated opportunistic infection, intercurrent illness, drug toxicity or any other condition such that in the judgment of the investigator the patient would not be able to take or continue a prescribed antiretroviral regimen
Malignancy requiring chemotherapy or radiotherapy
Known hypersensitivity to any of the prescribed antiretroviral drugs or formulation components
Evidence of alcohol and/or drug or substance abuse that in the judgment of the investigator would likely result in the patient being unreliable in fulfilling the conditions of the protocol
History of psychological illness or conditions that in the judgment of the investigator might interfere with the patient's ability to understand the requirements of the study
History of drug non-adherence that in the judgment of the investigator would result in the patient being unreliable in fulfilling the conditions of this protocol
Patients who had received an investigational new drug within the last 4 weeks
Currently taking, or anticipate taking during the course of the study, any drug contraindicated with the antiretroviral drugs they have been randomized to receive