Lornoxicam With Low Dose Ketamine Versus Pethidine to Control Pain of Acute Renal Colic

Ain Shams University

Status

Completed

Conditions

Renal Colic

Treatments

Drug: Lornoxicam and mepridine

Study type

Interventional

Funder types

Other

Identifiers

NCT03780556

ASU 5418

Details and patient eligibility

About

Patients with acute renal colic divided into 2 groups. Group L administered ornoxicam and Group P administered pethidine and VAS was recorded for both groups.

Full description

Prospective, randomized, double blind clinical study including 120 patients with acute renal pain admitted in emergency department. They were randomly assigned to one of two groups using a computer-generated table. Group L received lornoxicam 8 mg IV plus 0.15 mg.kg-1 ketamine and Group P received pethidine 50 mg IV. Parameters were observed at baseline and after 0, 15, 30, 45 and 1 hour of drug treatment. The efficacy of the drug was measured by observing: patient rated pain, time to pain relief, rate of pain recurrence, the need for rescue analgesia, adverse events and functional status.

Enrollment

120 patients

Sex

All

Ages

20 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients, who did not administer any analgesics at least within the last two hours. - -
Patients aged between 20-60 years.

Exclusion criteria

Patients with previous renal surgery
liver and renal failure
hypersensitivity to lornoxicam, ketamine and pethidine, history of peptic ulcer,
gastrointestinal bleeding and perforation,
hypertensive and history of cardiac diseases
pregnancy and lactation and
urine examination showing more than 5 leukocytes suggestive of pyuria.
patients with hyperthyroidism are excluded