Losartan and Emotion Processing

University of Electronic Science and Technology of China

Status: Unknown

Conditions: Healthy

Treatments: Drug: Placebo Oral Tablet; Drug: Losartan

Study type: Interventional

Funder types: Other

Identifiers

NCT03396523

UESTC-neuSCAN-25

Details and patient eligibility

About

The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear

Full description

In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.

Enrollment: 70 estimated patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

• history of head injury
• medical or psychiatric illness
• hypertension

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups, including a placebo group

Losartan group

Experimental group

Treatment:

Drug: Losartan

Placebo group

Placebo Comparator group

Treatment:

Drug: Placebo Oral Tablet