Low and Moderete Flow Anaesthesia on Haemodynamics

Umraniye Education and Research Hospital

Status: Not yet enrolling

Conditions: Arrhythmias Cardiac; Hemodynamics Instability; Cerebral Oxygenation

Treatments: Device: low- medium flow anesthetic machine; Device: Sevoflurane (Volatile Anesthetic)

Study type: Interventional

Funder types: Other

Identifiers

NCT06871371

LFATUGCE

Details and patient eligibility

About

The study topic investigates the potential advantages of low-flow anesthesia in terms of physiological protection and resource saving.

Full description

The study aims to compare the effects of low and normal flow sevoflurane anesthesia on the frontal QRS-T angle and cerebral oxygenation in laparoscopic cholecystectomy surgery. The primary objective was to evaluate the effects of low-flow anesthesia on hemodynamic stability and arrhythmia risk; the secondary objective was to compare the total sevoflurane consumption in both methods.

Enrollment: 76 estimated patients

Sex: All

Ages: 17 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• being ASA1-2 status
• between the ages of 18-70
• who are planned for laparoscopic cholecystectomy

Exclusion criteria

• Patients who refuse to give informed consent
• Pregnant and breastfeeding patients
• Morbidly obese patients (Body mass index over 40)
• Patients with uncontrolled diabetes mellitus, with serious cardiovascular, pulmonary, renal, hepatic disease, obstructive sleep apnea, with electrolyte imbalance- Those with a history of alcohol or drug abuse, with perioperative hemodynamic instability
• Patients using drugs known to prolong myocardial repolarization
• inability to increase SPO2 above 95 despite necessary intervention

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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76 participants in 2 patient groups

low flow anesthesia

Active Comparator group

Description:

Maintenance of anaesthesia with low-flow anaesthesia

Treatment:

Device: low- medium flow anesthetic machine

Device: Sevoflurane (Volatile Anesthetic)

Medium Flow Anesthesia

Active Comparator group

Description:

Maintenance of anaesthesia with medium-flow anaesthesia

Treatment:

Device: low- medium flow anesthetic machine

Device: Sevoflurane (Volatile Anesthetic)