Low Contrast Agent and Radiation Dose Protocol for Liver CT in Patients With HCC

Seoul National University

Status: Completed

Conditions: Hepatocellular Carcinoma

Treatments: Other: Deep-learning based contrast boosting algorithms; Radiation: Low radiation dose CT; Drug: Low contrast dose CT; Drug: Conventional CT (contrast agent); Radiation: Conventional CT (radiation)

Study type: Interventional

Funder types: Other

Identifiers

NCT04722120

SNUH-2016-2272

Details and patient eligibility

About

The purpose of this study is to investigate the image quality and clinical feasibility of double low-dose liver computed tomography using a deep-learning-based iodine contrast boosting algorithm in participants at high risk for hepatocellular carcinoma.

Full description

The purpose of this study is to investigate the image quality (CNR, subjective inage quality, vessel and lesion conspicuity) and clinical feasibility (rate of lesion detection) of double low-dose liver computed tomography using a deep-learning-based iodine contrast boosting algorithm in participants at high risk for hepatocellular carcinoma.

Enrollment: 68 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Liver cirrhosis
• Tumor marker (aFP, PIVKA) elevation
• Nodular lesion on USG
• Received RFA for HCC

Exclusion criteria

• hypersensitivity at iodine
• GFR under 30
• BMI over 30
• Nursing or pregnant women
• enrolled the other study

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

68 participants in 2 patient groups

Conventional liver CT

Active Comparator group

Description:

Underwent conventional liver CT on HCC high-risk patient

Treatment:

Drug: Conventional CT (contrast agent)

Radiation: Conventional CT (radiation)

Double low dose CT

Experimental group

Description:

Underwent double low dose liver CT with 30% lower radiation dose and 20% contrast media on HCC high-risk patient

Treatment:

Drug: Low contrast dose CT

Other: Deep-learning based contrast boosting algorithms

Radiation: Low radiation dose CT