Low Creatinine Level and Respiratory Failure

Osijek University Hospital

Status: Completed

Conditions: Respiratory Insufficiency; Muscle Weakness; Intensive Care Unit

Treatments: Diagnostic Test: Serum creatinine levels

Study type: Observational

Funder types: Other

Identifiers

NCT04368325

OsijekUH-7

Details and patient eligibility

About

Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients. The investigators compared the outcomes of participants with low creatinine levels with subsequent ICU participants admitted into ICU in the tertiary hospital.

Full description

The investigators have found a total of 46 participants with low creatinine levels and compared their outcome data with a group of participants with normal or high creatinine levels (control group, N=61). Low creatinine was defined as values of ≤40 μmol/L. Demographic data, type of admission (medical vs. surgical), hemoglobin values, CRP, and ventilator days were compared. A statistical analysis was performed using chi square and T-test.

Enrollment: 107 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Inclusion criteria for study group was value of ≤40 µmol/L serume creatinine level during hospitalization in ICU from July 2015 to November 2016.

Exclusion criteria

• Patients who were younger than 18 years

Trial design

107 participants in 2 patient groups

Study group

Description:

Total of 46 patients with low serum creatinine levels whose values were obtained from the central laboratory with inclusion criteria (\< 40mmol/L)

Treatment:

Diagnostic Test: Serum creatinine levels

Control group

Description:

A total of 61 consecutive patients were obtained who were treated in ICU CHC Osijek, according to the date of admission.

Treatment:

Diagnostic Test: Serum creatinine levels