Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies

Ministry of Science and Technology of the People´s Republic of China

Status and phase: Unknown; Phase 4

Conditions: Twin Pregnancy; Preeclampsia; Fetal Growth Restriction; Preterm Birth

Treatments: Drug: Aspirin 100mg

Study type: Interventional

Funder types: Other

Identifiers

NCT04051567

M2017047

Details and patient eligibility

About

Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth. Low-dose aspirin was recommend by American College of Obstetricians and Gynecologists (ACOG) during pregnancy. In this trial, the investigators suppose that aspirin used in twin-pregnancies could improve adverse pregnancy outcomes.

Enrollment: 425 estimated patients

Sex: Female

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Twin pregnancy diagnosed by ultrasound and maternal age ranged from 18 to 55 years, Gestational age was less than 16w

Exclusion criteria

• Diagnosed fetal anomalies, history of cervical cerclage, contraindications of aspirin, pre-existing renal or liver diseases or abnormal functions, coagulation disorders, history of PE, preterm birth or FGR, chronic hypertension

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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425 participants in 2 patient groups

LDA group

Experimental group

Treatment:

Drug: Aspirin 100mg

NC group

No Intervention group