Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments

University of Oulu

Status: Completed

Conditions: Intrauterine Fetal Growth Restriction; Preeclampsia; Extrauterine Pregnancy; Miscarriage Less Than 12 Gestational Weeks; Pregnancy

Treatments: Drug: Acetylsalicylic acid; Drug: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00683202

56/2001

Details and patient eligibility

About

In this study we hypothesized that low-dose aspirin therapy (100 mg daily) improves ovarian responsiveness, uterine haemodynamics and clinical pregnancy rates in unselected subjects undergoing IVF/ICSI when the treatment is started concomitantly with controlled ovarian hyperstimulation.

Full description

Low-dose acetylsalicylic acid irreversibly inhibits the cyclo-oxygenase enzyme in platelets, thus preventing the synthesis of thromboxane, which causes vasoconstriction and platelet aggregation. By this mechanism low-dose aspirin may enhance ovarian and uterine blood flow and tissue perfusion and thus improve ovarian responsiveness for gonadotrophins and endometrial receptivity for implantation. Randomized controlled studies and meta-analyses on the low-dose aspirin therapy to improve IVF/ICSI outcome or uterine hemodynamics have revealed conflicting results.

Enrollment: 374 patients

Sex: Female

Ages: 18 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age < 40 years
• < 4 previous ovarian stimulations

Exclusion criteria

• allergy for acetylsalicylic acid

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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374 participants in 2 patient groups, including a placebo group

1

Active Comparator group

Description:

Acetylsalicylic acid 100 mg daily perorally

Treatment:

Drug: Acetylsalicylic acid

2

Placebo Comparator group

Description:

Placebo daily perorally

Treatment:

Drug: Placebo