Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease

Dana-Farber Cancer Institute

Status: Completed

Conditions: Lung Cancer

Treatments: Procedure: chest computed tomography scan

Study type: Interventional

Funder types: Other

Identifiers

NCT00601146

06-122

Details and patient eligibility

About

This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. Currently, the practice is to recommend annual low-dose chest CT scans in survivors of Hodgkin's disease who have received prior chest radiation treatment and who have at least a moderate smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner.

Full description

• Participants will undergo a chest computed tomography (CT) scan once a year for a 3-year period.

Enrollment: 39 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 5 years or longer from initial Hodgkin's disease diagnosis
• Current age 18 or older
• Received mediastinal irradiation and/or alkylating-agent based chemotherapy
• Smoking history of 10-pack years or more, or current smoker
• Pre-approval from the participant's insurance company for the CT study

Exclusion criteria

• Patients with a history of lung cancer
• Currently receiving treatment for another cancer diagnosis
• Known diagnosis of any metastatic cancer
• Pregnant women

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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39 participants in 1 patient group

Low-dose Chest CT screening

Experimental group

Description:

Annual low-dose Chest CT screening

Treatment:

Procedure: chest computed tomography scan