Low-dose Combination of Three Antihypertensive Drugs (3D)

University of Roma La Sapienza

Status and phase: Unknown; Phase 4

Conditions: Arterial Hypertension

Treatments: Drug: Reaptan (perindopril, amlodipine); Drug: Tripliam (perindopril, indapamide, amlodipine)

Study type: Interventional

Funder types: Other

Identifiers

NCT02710552

123/D/2016

Details and patient eligibility

About

The aim of the study is to compare the efficacy and safety of low-dose combination of three antihypertensive drugs versus fixed high-dose combination of two antihypertensive drugs in arterial hypertension

Full description

The aim of the study is to compare the efficacy and safety of commercially available low-dose combination of three antihypertensive drugs versus commercially available fixed high-dose combination of two antihypertensive drugs in arterial hypertension

Enrollment: 100 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients with arterial hypertension resistant to monotherapy

Exclusion criteria

None

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Three antihypertensive Drugs

Active Comparator group

Description:

Patients will be treated with Tripliam, that is a commercially available fixed low-dose combination of three antihypertensive drugs, that is 5 mg/daily perindopril, 1,25 mg/daily indapamide and 5 mg/day amlodipine

Treatment:

Drug: Tripliam (perindopril, indapamide, amlodipine)

Two antihypertensive drugs

Active Comparator group

Description:

Patients will be treated with Reaptan, that is a commercially available fixed high-dose combination of two antihypertensive drugs, that is 10 mg/daily perindopril and 5 mg/day amlodipine

Treatment:

Drug: Reaptan (perindopril, amlodipine)