Low-dose Contrast Media for Low-kVp Abdomen CT

Bohyun Kim

Status: Enrolling

Conditions: Appendicitis Acute

Treatments: Diagnostic Test: Weight-adjusted low-dose contrast media paired with low-radiation dose abdomen CT

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05878665

DLD-001

Details and patient eligibility

About

The purpose of this clinical study is to test the performance of low radiation dose abdominal CT combined with low dose contrast media for the diagnosis of acute appendicitis in young patients. The main questions to be answered are:

1, Can low-dose contrast media paired with low-dose radiation CT of the abdomen provide acceptable diagnostic accuracy in acute appendicitis? 2. How much radiation dose can be saved by using low radiation dose abdominal CT in combination with low dose contrast media?

Enrollment: 292 estimated patients

Sex: All

Ages: 19 to 44 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients in the emergency department with suspected acute appendicitis based on clinical examination
• Patients scheduled for contrast-enhanced CT of the abdomen and pelvis for diagnosis of suspected acute appendicitis.

Exclusion criteria

• Patients who decline to participate
• Contraindications to contrast-enhanced CT (eGFR < 30 mL/min/173 m^2 or pregnant)
• BMI >= 30.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

292 participants in 1 patient group

Double low-dose CT

Experimental group

Description:

Weight-adjusted low-dose contrast media paired with low-radiation dose abdomen CT

Treatment:

Diagnostic Test: Weight-adjusted low-dose contrast media paired with low-radiation dose abdomen CT