Low Dose Effects of X-rays in Pediatric Patients Undergoing a CT Examination. (PedCTBe)

University Ghent

Status: Completed

Conditions: Pediatric Patients Undergoing a Computed Tomography Examination

Treatments: Procedure: Blood test

Study type: Observational

Funder types: Other

Identifiers

NCT01518673

2010/708

Details and patient eligibility

About

Patients undergoing a computed tomography are exposed to a relatively high dose of X-rays. Pediatric patients are known to be very radiosensitive with respect to radiation induced cancer. Using the technique of scoring γ-H2AX foci in peripheral blood lymphocytes the most important lesions to the genetic material DNA, double strand breaks induced by CT X-rays can be detected. The technique will be applied in a multicenter setting for evaluation of X-effects induced by a computed tomography examination in a population of pediatric patients. To this end a blood sample will be taken from the patients before and after the examination.

Enrollment: 140 patients

Sex: All

Ages: Under 12 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• pediatric patients wearing a catheter

Exclusion Criteria:

Trial design

140 participants in 1 patient group

X-rays

Treatment:

Procedure: Blood test