Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy

Helio's Health

Status: Completed

Conditions: Performance With Respiratory Exercise Device; Intubating Conditions; Postoperative Myalgia

Treatments: Drug: Mivacurium; Drug: Succinylcholine

Study type: Interventional

Funder types: Industry

Identifiers

NCT01966484

HSK003

Details and patient eligibility

About

Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A alternative is the application of low dose mivacurium, reversed with neostigmine. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), patient satisfaction and the postoperative performance with respiration exercise device for these two muscle relaxants.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 yr
• scheduled for elective rigid bronchoscopy

Exclusion criteria

• known neuromuscular disease
• significant hepatic or renal dysfunction
• family history of malignant hyperthermia
• known allergy to one of the drugs used in this protocol
• pregnancy or breastfeeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Succinylcholine

Active Comparator group

Description:

Patient receive succinylcholine as a muscle relaxant (0,5mg/kg) after induction of general anaesthesia for rigid bronchoscopy.

Treatment:

Drug: Succinylcholine

Mivacurium

Active Comparator group

Description:

Patients receive mivacurium (0,08mg/kg) as a muscle relaxant after induction of general anaesthesia for rigid bronchoscopy. At the end of the procedure and a twitch of 25% mivacurium was reversed with neostigmine (50 microg/kg) and atropin (10 microg/kg)

Treatment:

Drug: Mivacurium