Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial

Isfahan University of Medical Sciences

Status: Completed

Conditions: Knee Arthroplasty, Total

Treatments: Drug: Normal saline; Drug: Tranexamic Acid

Study type: Interventional

Funder types: Other

Identifiers

NCT02327117

392114

Details and patient eligibility

About

Total Knee Arthroplasty (TKA) is a common orthopedic surgery usually leads to Bleeding. The null hypothesis of this study was that TA has no effect on post surgical bleeding in patients undergoes TKA.

Enrollment: 90 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals with osteoarthritis who indicated for primary TKA.

Exclusion criteria

• Previous history of ceberovascular diseases
• Previous history of myocardial infarction
• Candidates for bilateral TKA

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups, including a placebo group

Tranexamic acid

Experimental group

Treatment:

Drug: Tranexamic Acid

Normal Saline

Placebo Comparator group

Treatment:

Drug: Normal saline