Low Dose Radiation Therapy for Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2), COVID-19 (COVID-RT-01)

University Hospital Basel

Status: Completed

Conditions: Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2)

Treatments: Other: Sham irradiation; Radiation: Low Dose Radiation Therapy (LD-RT)

Study type: Interventional

Funder types: Other

Identifiers

NCT04598581

2020-02047qu20Papachristofilou

Details and patient eligibility

About

This study is to analyse the efficacy of LD-RT for treatment of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2).

Full description

Management of patients with SARS-CoV-2 presents a great challenge in the ongoing pandemic. The inflammatory reaction, evident in the later stages of the disease, is linked with high mortality rates. Pharmaceutical interventions at this stage often do not achieve the desired effects. Low Dose Radiation Therapy (LD-RT) has been utilized for treatment of inflammatory conditions because of its immunomodulatory effects. Thus, LD-RT may be an option in SARS-CoV-2 based on pre-clinical models and early clinical data. This study is to analyse the efficacy of LD-RT for treatment of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2).

Enrollment: 22 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age of male patients >40 years
• Age of female patients >50 years
• Patients with SARS-CoV-2 requiring mechanical ventilation
• Informed consent obtained by the legal representative of the patient

Exclusion criteria

• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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22 participants in 2 patient groups

Low Dose Radiation Therapy (LD-RT)

Active Comparator group

Treatment:

Radiation: Low Dose Radiation Therapy (LD-RT)

Sham irradiation

Sham Comparator group

Treatment:

Other: Sham irradiation