Low-dose Spinal Morphine for Post-Thoracotomy Pain After Video-Assisted Thoracoscopic Surgery

Mahidol University

Status and phase: Completed; Phase 4

Conditions: Video-assisted Thoracoscopic Surgery

Treatments: Other: control; Drug: Morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT01917448

2556

Details and patient eligibility

About

One-thirds of patients underwent video-assisted thorascopic surgery still have severe pain. Therefore we want to demonstrate weather 0.15 mg spinal morphine would reduce 24 hour postoperative requirement comparing to control group.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA (American Society of Anesthesiologist) physical status I to III,
• Undergoing elective video-assisted thoracoscopic surgery at Siriraj and Thammasart Hospitals
• capable of using a patient-controlled analgesia (PCA) machine
• understanding the numeric rating scale (NRS) score for pain assessment.

Exclusion criteria

• history of allergy to the study drugs
• bleeding disorder
• infection of the back
• refusing spinal anesthesia
• history of cerebrovascular disease
• using postoperative ventilator support were excluded

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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36 participants in 2 patient groups

Control

Sham Comparator group

Description:

The skin will be injected with local anesthetic without spinal block

Treatment:

Other: control

Spinal morphine

Active Comparator group

Description:

0.15 mg spinal morphine

Treatment:

Drug: Morphine