Low-Flow Anesthesia and Open-Heart Surgery

Çağrı Özdemir

Status: Not yet enrolling

Conditions: Open-heart Surgery; Low-flow Anesthesia; Hemodynamics

Study type: Observational

Funder types: Other

Identifiers

NCT07040735

2025-146

Details and patient eligibility

About

Low-flow anesthesia (LFA) is a technique in which at least 50% of the exhaled air, after carbon dioxide absorption, is mixed with a certain amount of fresh gas and returned to the patient during the next inspiration. In 1974, R. Virtue defined minimal flow anesthesia (MFA) as 0.5 L/min. In 1984, Baker and Simionescu classified LFA as 0.5-1 L/min and MFA as 0.25-0.5 L/min. The aim of this study is to investigate whether there are hemodynamic differences between open-heart surgery cases performed with LFA at different fresh gas flow rates.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

-≥18 years and scheduled for open-heart surgery patients

-ASA I-II-III-IV physical class

Exclusion criteria

• Emergency cases
• Patients under 18 years of age
• Patients who have had open heart surgery before
• Patients for whom the use of inhaled anesthetic agents is contraindicated
• Patients who do not sign a voluntary consent form

Trial design

80 participants in 4 patient groups

Group 1

Description:

Followed using Bispectral Index (BIS) with 4% Sevoflurane and fresh gas flow set at 0.5 L/min

Group 2

Description:

Followed using Minimum Alveolar Concentration (MAC) with 4% Sevoflurane and fresh gas flow set at 0.5 L/min

Group 3

Description:

Followed using BIS with 4% Sevoflurane and fresh gas flow set at 1 L/min

Group 4

Description:

Followed using MAC with 4% Sevoflurane and fresh gas flow set at 1 L/min