Low Flow Anesthesia Without Initial High Flow Phase

Kahramanmaraş Sütçü İmam University (KSU)

Status: Completed

Conditions: Volatile Anesthetic Consumption; Low Flow Anesthesia

Treatments: Procedure: Conventional Low flow Anesthesia; Procedure: Low Flow Anesthesia with fixed fresh gas flow rate

Study type: Interventional

Funder types: Other

Identifiers

NCT03955406

KSU 2017-15

Details and patient eligibility

About

The aim of the study is to compare the effectiveness of conventional low flow anesthesia (LFA) with initial high fresh gas flow ( 4L/min) for 10 minutes and LFA with fixed fresh gas flow rate (1L/min).

Enrollment: 80 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1-3
• scheduled for surgery under general anesthesia with endotracheal intubation

Exclusion criteria

• hemodynamic instability
• emergency cases
• expected anesthesia duration < 60 min
• patient refusal

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

Conventional group

Active Comparator group

Description:

After standart intravenous anesthesia induction end endotracheal intubation desflurane vaporizer will be set at 6% with fresh gas flow rate 4 L/min (50% O2, 50% air) until the EtAA concentration reaches 0.7 MAC (minimum alveolar concentration) Then, the desflurane vaporizer will be at a 1% higher value than the EtAA concentration required to achieve 0.7 MAC. And after 10 minutes fresh gas flow rate will be reduced to 1L/min.

Treatment:

Procedure: Conventional Low flow Anesthesia

Fixed Fresh Gas Flow Rate group

Active Comparator group

Description:

After standart intravenous anesthesia induction end endotracheal intubation desflurane vaporizer will be set at 18% with fresh gas flow rate 1 L/min (50% O2, 50% air) until the EtAA concentration reaches 0.7 MAC (minimum alveolar concentration) Then, the desflurane vaporizer will be at a 2% higher value than the EtAA concentration required to achieve 0.7 MAC.

Treatment:

Procedure: Low Flow Anesthesia with fixed fresh gas flow rate